Proteomics of synapse
نویسندگان
چکیده
منابع مشابه
Proteomics of synapse.
The brain is the most complex and dynamically organized organ with a high level of computational ability that enables the acquisition and integration of information in order to generate appropriate responses to environmental and physiological inputs. Pivotal to its function is its extensive neuronal connectivity, due in particular to the 10 synaptic connections of the 100 billion central neuron...
متن کاملInteraction proteomics of synapse protein complexes
The brain integrates complex types of information, and executes a wide range of physiological and behavioral processes. Trillions of tiny organelles, the synapses, are central to neuronal communication and information processing in the brain. Synaptic transmission involves an intricate network of synaptic proteins that forms the molecular machinery underlying transmitter release, activation, an...
متن کاملPharmaceutical Advances and Proteomics Researches
Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...
متن کاملSynapse proteomics of multiprotein complexes: en route from genes to nervous system diseases.
Proteomic experiments have produced a draft profile of the overall molecular composition of the mammalian neuronal synapse. It appears that synapses have over 1000 protein components and the mapping of their interactions, organization and functions will lead to a global view of the role of synapses in physiology and disease. A major functional subcomponent of the synaptic machinery is a multipr...
متن کاملTargeted Proteomics And Biochemical Fractionation: New Tools For Deciphering The Synapse In Schizophrenia
Schizophrenia is a chronic and debilitating psychiatric illness affecting approximately 1% of the world's population for which there is no cure and treatment options are limited. Poor understanding of disease pathology and the difficulty in modeling psychiatric symptoms in animal models has hindered the search for a cure. Despite these difficulties great progress has been made on several fronts...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2006
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-006-0608-x